E-GEOD-37609 - Transcription profiling by array of olfactory epithelium from Atf5+/+ and Atf5-/- mice
Released on 30 October 2012, last updated on 30 April 2015
We have found that the expression pattern of Atf5 is highly restricted to the olfactory system, strongly suggesting that Atf5 is an olfactory sensory neuron-specific transcription factor. To test this possiblity, we compared gene expression profiles in olfactory epithelium (septa and turbinates) from Atf5+/+ and Atf5-/- mice. Olfactory septa and turbinates were dissected from Atf5+/+ and Atf5-/- P0 pups from different litters (n=3 for each genotype) and pooled into a single sample. Three independent samples were prepared for each genotype.
transcription profiling by array
Sara Deibler <email@example.com>, Michael R Green, Shu-Zong Wang
Transcription factor ATF5 is required for terminal differentiation and survival of olfactory sensory neurons. Wang SZ, Ou J, Zhu LJ, Green MR.