Please note that we have stopped the regular imports of Gene Expression Omnibus (GEO) data into ArrayExpress. This may not be the latest version of this experiment.
E-GEOD-37234 - Effect of obacunone on Salmonella Typhimurium transcriptome
Released on 21 August 2012, last updated on 3 May 2014
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
Obacunone is a limonoids present in Citrus species. We previously reported that obacunone was inhibitory to the cell-cell signaling in Vibrio harveyi and Escherichia coli O157:H7. In the present work we evaluated the effect of obacunone on the food borne pathogen Salmonella Typhimurium LT2 using cDNA microarray. The results demonstrate that obacunone exerts an antivirulence effect on S. Typhimurium LT2 by repressing SPI1 and SPI2. Furthermore, the effect of obacunone seems to be dependent upon EnvZ. One condition experiment, obacunone treated versus DMSO treated. Biological replicates: 3 control, 3 treatment, hybridized in dye-swapped design
transcription profiling by array
Amit Vikram, Bhimanagouda S Patil, G K Jayaprakasha, Palmy R Jesudhasan, Suresh D Pillai
Obacunone Represses Salmonella Pathogenicity Islands 1 and 2 in an envZ-Dependent Fashion. Vikram A, Jayaprakasha GK, Jesudhasan PR, Pillai SD, Patil BS. , PMID:22843534