E-GEOD-37147 - Bronchial airway gene expression reflects a COPD-associated field of injury that changes with disease severity and is reversible with therapy

Released on 22 March 2013, last updated on 31 March 2013
Homo sapiens
Samples (269)
Array (1)
Protocols (6)
RNA was isolated from bronchial brushings obtained from current and former smokers with and without COPD. mRNA expression was profiled using Affymetrix Human Gene 1.0 ST Arrays. RNA isolated from bronchial brushings was processed and hybridized to Affymetrix Human Gene 1.0 ST Arrays. A total of 269 arrays from 267 subjects were hybridized. Data from the 269 microarrays were used for RMA normalization. Data from 238 subjects was used in the analysis to determine the association of gene expression with COPD-related phenotypes.
Experiment type
transcription profiling by array 
A Dynamic Bronchial Airway Gene Expression Signature of COPD and Lung Function Impairment. Steiling K, van den Berge M, Hijazi K, Florido R, Campbell J, Liu G, Xiao J, Zhang X, Duclos G, Drizik E, Si H, Perdomo C, Dumont C, Coxson HO, Alekseyev YO, Sin D, Pare P, Hogg JC, McWilliams A, Hiemstra PS, Sterk PJ, Timens W, Chang JT, Sebastiani P, O'Connor GT, Bild AH, Postma DS, Lam S, Spira A, Lenburg ME. , Europe PMC 23471465