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E-GEOD-36947 - Elevating Sox2 levels deleteriously affects the growth of glioblastoma and medulloblastoma cells

Released on 25 August 2012, last updated on 26 September 2012
Homo sapiens
Samples (2)
Array (1)
Protocols (8)
Induction of the transcription factor Sox2 from a doxycycline-inducible promoter in iSox2-DAOY medulloblastoma cells. Affymetrix microarrays were used to characterize the gene expression profile of iSox2-DAOY cells in the absence and presence of doxycycline. Human DAOY medulloblastoma cells were engineered to express epitope tagged Sox2 under the control of a doxycycline inducible promoter, to produce iSox2-DAOY cells. iSox2-DAOY cells were FACS sorted into CD133 low and high populations. The CD133 low population was cultured in the absence and presence of 0.5 µg/mL doxycycline for 24 hours. RNA was extracted from cells cultured without and with doxycycline, and was used for microarray analysis.
Experiment type
transcription profiling by array 
Angie Rizzinio <>, Angie Rizzino, Jesse L Cox, Phillip J Wilder
Investigation descriptionE-GEOD-36947.idf.txt
Sample and data relationshipE-GEOD-36947.sdrf.txt
Raw data (1)
Processed data (1)
Array designA-AFFY-141.adf.txt
R ExpressionSetE-GEOD-36947.eSet.r