E-GEOD-3681 - PHA-4 organogenesis
Submitted on 25 November 2005, released on 25 November 2005, last updated on 27 March 2012
The pha-4 locus encodes a forkhead box A (FoxA/HNF3) transcription factor homolog that specifies organ identity for Caenorhabditis elegans pharyngeal cells. We used microarrays to identify pharyngeal genes and analyzed those genes to determine which were direct PHA-4 targets. Our data suggest that PHA-4 directly activates most or all pharyngeal genes. Furthermore, the relative affinity of PHA-4 for different TRTTKRY (R = A/G, K = T/G, Y = T/C) elements modulates the onset of gene expression, providing a mechanism to activate pharyngeal genes at different developmental stages. We suggest that direct transcriptional regulation of entire gene networks may be a common feature of organ identity genes. A genotyping experiment design type classifies an individual or group of individuals on the basis of alleles, haplotypes, SNP's. Computed
unknown experiment type
Stanford Microarray Database <firstname.lastname@example.org>, Stuart Kim, Susan Mango
Regulation of organogenesis by the Caenorhabditis elegans FoxA protein PHA-4. Gaudet J, Mango SE.