Please note that we have stopped the regular imports of Gene Expression Omnibus (GEO) data into ArrayExpress. This may not be the latest version of this experiment.
E-GEOD-35976 - Genome wide array analysis of endosseous implant adherent cellular phenotypes
Released on 27 September 2012, last updated on 18 October 2012
Objective: to identify the early molecular processes involved in osseointegration associated with a micro roughened and nanosurface featured implants. Thirty-two titanium implants with surface topographies exhibiting nanoscale features (AT-I) and microrough surface without nanoscale features (AT-II) were placed in the tibiae of 8 rats and subsequently harvested at 2 and 4 days after placement. Total RNA was isolated from cells adherent to retrieved implants. A whole genome microarray using the Affymetrix Rat gene 1.1 ST Array was used to describe the gene expression profiles that were differentially regulated by the implant surfaces.
transcription profiling by array
Lyndon Cooper <email@example.com>, Ghadeer N Thalji, Lyndon F Cooper
Comparative molecular assessment of early osseointegration in implant-adherent cells. Thalji G, Gretzer C, Cooper LF. , PMID:22884725