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E-GEOD-35151 - Genome-wide occupancy profile of Tbx3, Gata4, Nkx2-5 and p300 in adult mouse whole heart

Status
Released on 22 June 2012, last updated on 11 March 2013
Organism
Mus musculus
Samples (5)
Protocols (7)
Description
The contraction pattern of the heart relies on the activation and conduction of the electrical impulse. Perturbations of cardiac conduction have been associated with congenital and acquired arrhythmias as well as cardiac arrest. The pattern of conduction depends on the regulation of heterogeneous gene expression by key transcription factors and transcriptional enhancers. Here, we assessed the genome-wide occupation of conduction system–regulating transcription factors TBX3, NKX2-5, and GATA4 and of enhancer-associated coactivator p300 in the mouse heart, uncovering cardiac enhancers throughout the genome. Examination of 3 cardiac transcription factors and p300 in adult mouse heart
Experiment type
ChIP-seq 
Contacts
Vincent M. Christoffels <v.m.christoffels@amc.nl>, Malou van den Boogaard, Phil Barnett, Vincent M Christoffels
Citation
Genetic variation in T-box binding element functionally affects SCN5A/SCN10A enhancer. van den Boogaard M, Wong LY, Tessadori F, Bakker ML, Dreizehnter LK, Wakker V, Bezzina CR, 't Hoen PA, Bakkers J, Barnett P, Christoffels VM. , PMID:22706305
MINSEQE
Exp. designProtocolsVariablesProcessedSeq. reads
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