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E-GEOD-35139 - Congenic dissection of a major QTL for methamphetamine sensitivity implicates epistasis

Released on 18 January 2012, last updated on 23 January 2012
Mus musculus
Samples (28)
Array (1)
Protocols (7)
We identified a congenic mouse with an introgressed region from the A/J donor inbred strain on an inbred C57BL/6J background that showed a reduced locomotor stimulant response to methamphetamine. We conducted microarray analysis of the striatum from drug-naive female and male mice that were 6-9 weeks old. The congenic region is on chromosome 11 and spans approximately 84-96 Mb. There were two groups of mice used in the analysis: B6 control mice versus congenic mice. Congenic mice were collapsed across heterozygous and homozygous genotypes. All mice are on a C57BL/6J background. Congenic mice differ only on chromosome 11 where they contain the introgressed A/J alleles from 84-96 Mb. 14 C57BL/6J wildtype mice and 14 B6.A/J congenic mice (84-96 Mb region from A/J strain) were examined for gene expression differences using striatal tissue (left and right punches pooled). All mice were drug-naïve and were 6-9 weeks old at the time of sacrifice.
Experiment type
transcription profiling by array 
Camron D Bryant <>, Abraham Palmer, Greta Sokoloff, Loren A Kole, Michael A Guido
Investigation descriptionE-GEOD-35139.idf.txt
Sample and data relationshipE-GEOD-35139.sdrf.txt
Raw data (1)
Processed data (1)
Array designA-AFFY-130.adf.txt
R ExpressionSetE-GEOD-35139.eSet.r