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E-GEOD-33878 - Transcription profiling by array of mouse thymic medullary epithelial cells mutant for Aire

Status
Released on 23 November 2011, last updated on 30 April 2015
Organism
Mus musculus
Samples (6)
Array (1)
Protocols (7)
Description
The aim of this study is to analyze the transcriptional effects of Aire deficiency in the thymus, using the Affymetrix MoGene platform to analyze variation in exon usage MECs were isolated from 4-6 wk-old WT or Aire KO ((B6xNOD)F1 background) mice. Three WT and three Aire-KO mice taken individually were used.
Experiment types
transcription profiling by array, genetic modification design
Contacts
CBDM Z. Lab <cbdm@hms.harvard.edu>, Christophe Benoist, Matthieu Giraud
Citation
Aire unleashes stalled RNA polymerase to induce ectopic gene expression in thymic epithelial cells. Giraud M, Yoshida H, Abramson J, Rahl PB, Young RA, Mathis D, Benoist C.
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-33878.idf.txt
Sample and data relationshipE-GEOD-33878.sdrf.txt
Raw data (1)E-GEOD-33878.raw.1.zip
Processed data (1)E-GEOD-33878.processed.1.zip
Array designA-AFFY-130.adf.txt
Links