Please note that we have stopped the regular imports of Gene Expression Omnibus (GEO) data into ArrayExpress. This may not be the latest version of this experiment.
E-GEOD-33878 - Transcription profiling by array of mouse thymic medullary epithelial cells mutant for Aire
Released on 23 November 2011, last updated on 30 April 2015
The aim of this study is to analyze the transcriptional effects of Aire deficiency in the thymus, using the Affymetrix MoGene platform to analyze variation in exon usage MECs were isolated from 4-6 wk-old WT or Aire KO ((B6xNOD)F1 background) mice. Three WT and three Aire-KO mice taken individually were used.
transcription profiling by array, genetic modification design
CBDM Z. Lab <email@example.com>, Christophe Benoist, Matthieu Giraud
Aire unleashes stalled RNA polymerase to induce ectopic gene expression in thymic epithelial cells. Giraud M, Yoshida H, Abramson J, Rahl PB, Young RA, Mathis D, Benoist C.