E-GEOD-31950 - Profiling fibrotic lung in TGFb1-Tg mice

Status
Released on 22 March 2013, last updated on 2 June 2014
Organism
Mus musculus
Samples (16)
Array (1)
Protocols (7)
Description
Transgenic (Tg) mice over-expressing TGFb1 in a lung-specific manner display airway inflammation and fibrosis, phenotypes relevant to human COPD and asthma. This model system provides a platform for identifying and validating genes/pathways involved in these disease pathogeneses. The TGFb1-Tg mice lung profiling data was analyzed by identifying genes that were up- and down-regulated at selected p value and fold change in the lung of TGFb1-Tg mice compared to the corresponding wild type controls.
Experiment type
transcription profiling by array 
Contacts
Bin Zhang, I-Ming Wang
Citation
Systems analysis of eleven rodent disease models reveals an inflammatome signature and key drivers. Wang IM, Zhang B, Yang X, Zhu J, Stepaniants S, Zhang C, Meng Q, Peters M, He Y, Ni C, Slipetz D, Crackower MA, Houshyar H, Tan CM, Asante-Appiah E, O'Neill G, Luo MJ, Thieringer R, Yuan J, Chiu CS, Lum PY, Lamb J, Boie Y, Wilkinson HA, Schadt EE, Dai H, Roberts C. , Europe PMC 22806142
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-31950.idf.txt
Sample and data relationshipE-GEOD-31950.sdrf.txt
Processed data (1)E-GEOD-31950.processed.1.zip
Additional data (1)E-GEOD-31950.additional.1.zip
Array designA-GEOD-3677.adf.txt
Links