Please note that we have stopped the regular imports of Gene Expression Omnibus (GEO) data into ArrayExpress. This may not be the latest version of this experiment.
E-GEOD-26027 - Early dynamic transcriptomic changes as predictors of preoperative radiotherapy efficacy in patients with rectal cancer: a feasibility study
Released on 12 December 2011, last updated on 16 December 2011
With a view to developing novel biomarkers of the efficacy of radiotherapy in patients with rectal cancer, we measured gene expression profiles on biopsies taken before and during preoperative radiotherapy. Repeat biopsy did not increase toxicity. Radiotherapy induced the expression of genes involved in oxidative stress, signal transduction, apoptosis and immune response. Two rectum tumor biospsies for each patient (6 cases) : before RT and one hour after a dose of 7.2 Gy (4th fraction) during RT.
transcription profiling by array
Wilfried Gouraud <email@example.com>, Bruno Buecher, Emmanuel Rio, Josiane Charrier, Loïc Campion, Marc-André Mahé, Marie-Françoise Heymann, Michel Chérel, Pascal Jézéquel, Stéphane Supiot