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E-GEOD-26027 - Early dynamic transcriptomic changes as predictors of preoperative radiotherapy efficacy in patients with rectal cancer: a feasibility study

Status
Released on 12 December 2011, last updated on 16 December 2011
Organism
Homo sapiens
Samples (12)
Array (1)
Protocols (6)
Description
With a view to developing novel biomarkers of the efficacy of radiotherapy in patients with rectal cancer, we measured gene expression profiles on biopsies taken before and during preoperative radiotherapy. Repeat biopsy did not increase toxicity. Radiotherapy induced the expression of genes involved in oxidative stress, signal transduction, apoptosis and immune response. Two rectum tumor biospsies for each patient (6 cases) : before RT and one hour after a dose of 7.2 Gy (4th fraction) during RT.
Experiment type
transcription profiling by array 
Contacts
Wilfried Gouraud <geo@ncbi.nlm.nih.gov>, Bruno Buecher, Emmanuel Rio, Josiane Charrier, Loïc Campion, Marc-André Mahé, Marie-Françoise Heymann, Michel Chérel, Pascal Jézéquel, Stéphane Supiot
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-26027.idf.txt
Sample and data relationshipE-GEOD-26027.sdrf.txt
Raw data (1)E-GEOD-26027.raw.1.zip
Processed data (1)E-GEOD-26027.processed.1.zip
Array designA-AFFY-44.adf.txt
R ExpressionSetE-GEOD-26027.eSet.r
Links