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E-GEOD-25283 - DNA methylation profiling of somatic tissues from normal and trisomic fetuses

Status
Released on 6 May 2011, last updated on 27 March 2012
Organism
Homo sapiens
Samples (60)
Array (1)
Protocols (6)
Description
The DNA methylation profiles in normal and abnormal fetal development were investigated using Illumina GoldenGate Methylation Cancer Panel I. DNA methylation status of 1505 CpG dinucleotides located in the regulatory regions of 807 genes was measured in 5 somatic tissues (brain, kidney, lung, muscle and skin) from second-trimester elective terminations of eight normal, five trisomy 21 and four trisomy 18 fetuses. Bisulfite-converted DNA from 60 samples were hybridized to the Illumina GoldenGate Methylation Cancer Panel I array.
Experiment type
methylation profiling by array 
Contacts
Ryan Yuen <hkykchun@gmail.com>, Michael S Kobor, Ryan K Yuen, Wendy P Robinson
Citation
Extensive epigenetic reprogramming in human somatic tissues between fetus and adult. Yuen RK, Neumann SM, Fok AK, Penaherrera MS, McFadden DE, Robinson WP, Kobor MS. , PMID:21545704
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-25283.idf.txt
Sample and data relationshipE-GEOD-25283.sdrf.txt
Processed data (1)E-GEOD-25283.processed.1.zip
Array designA-GEOD-9183.adf.txt
Links