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E-GEOD-25196 - Fetal Rat Testis mRNA Expression after 50 mg/kg Dibutyl Phthalate Exposure

Status
Released on 25 April 2011, last updated on 27 March 2012
Organism
Rattus norvegicus
Samples (8)
Array (1)
Protocols (7)
Description
High dose level dibutyl phthalate (DBP) exposure of fetal rat testes in vivo inhibits testosterone production (i.e. endocrine disruption). Here, fetal testis mRNA levels were profiled following exposure to a DBP dose level that did not significantly reduce testosterone levels. The goal was to identify the constellation of gene expression changes that do not correlate with endocrine disruption. Fischer 344 rats were exposed via oral gavage of the dam to vehicle (corn oil) or 50 mg/kg (body weight) DBP daily from gestational day (GD) 12 to 20. The day after mating was defined as gestational day 0. Six hours after the final exposure on GD20, fetal testes were dissected and mRNA levels quantified using Affymetrix Rat Expression 230 2.0 microarrays.
Experiment type
transcription profiling by array 
Contacts
Kamin J Johnson, Qing Xia
Citation
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-25196.idf.txt
Sample and data relationshipE-GEOD-25196.sdrf.txt
Raw data (1)E-GEOD-25196.raw.1.zip
Processed data (1)E-GEOD-25196.processed.1.zip
Array designA-AFFY-43.adf.txt
R ExpressionSetE-GEOD-25196.eSet.r
Links