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E-GEOD-25100 - Expression data from CD19-positive splenic B cells isolated from 1-month old ID4+/-TCL1-tg and ID4+/+TCL1-tg mice

Status
Submitted on 3 November 2010, released on 4 November 2010, last updated on 10 June 2011
Organism
Mus musculus
Samples (6)
Array (1)
Protocols (6)
Description
The function of ID4 in CLL development was studied in vivo using TCL1 transgenic mouse model that develop leukemia similar to human CLL. TCL1 mice with ID4 single knockout gene have accelerated CLL progression. Results from the animal study suggest ID4 as a tumor suppressor gene that might regulate cell proliferation and apoptosis in B lymphocytes. Gene expression in CD19-positive splenic B cells collected from 1-month old ID4+/-TCL1-tg and ID4+/+TCL1-tg mice was compared by microarray, the goal is to find ID4-regulated genes involved in CLL development.
Experiment type
transcription profiling by array 
Contacts
lianbo yu <geo@ncbi.nlm.nih.gov>, Lianbo Yu, Shih-Shih Chen
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-25100.idf.txt
Sample and data relationshipE-GEOD-25100.sdrf.txt
Raw data (1)E-GEOD-25100.raw.1.zip
Processed data (1)E-GEOD-25100.processed.1.zip
Array designA-AFFY-45.adf.txt
R ExpressionSetE-GEOD-25100.eSet.r
Links