E-GEOD-2501 - Transcription profiling of murine leukemic T cells from Ikaros-deficient mice and wild type mice to identify critical gene expression events during T-cell leukemogenesis
Submitted on 6 April 2005, released on 4 September 2007, last updated on 27 March 2012
The experiment was to compare leukemic T cells from thymic lymphomas from homozygote mice for the IkL/L hypomorphic mutation and non-transformed thymocytes, either of WT or IkL/L genotype. The aim was to identify a gene expression signature specific to the IkL/L tumors.
transcription profiling by array, cell type comparison, co-expression, individual genetic characteristics
Notch activation is an early and critical event during T-Cell leukemogenesis in Ikaros-deficient mice. Alexis Dumortier, Robin Jeannet, Peggy Kirstetter, Eva Kleinmann, MacLean Sellars, Nuno R dos Santos, Christelle Thibault, Jochen Barths, Jacques Ghysdael, Jennifer A Punt, Philippe Kastner, Susan Chan. Mol Cell Biol 26(1):209-20 (2006)