Please note that we have stopped the regular imports of Gene Expression Omnibus (GEO) data into ArrayExpress. This may not be the latest version of this experiment.

E-GEOD-2487 - Transcription profiling of cell lines produced from premalignant tumors with induced sensence

Status
Submitted on 4 April 2005, released on 2 October 2007, last updated on 27 March 2012
Organism
Homo sapiens
Samples (10)
Array (1)
Protocols (3)
Description
Oncogene-induced senescence is a cellular response that may be crucial for protection against cancer development, but its investigation has so far been restricted to cultured cells that have been manipulated to overexpress an oncogene. Here we analyse tumours initiated by an endogenous oncogene, ras, and show that senescent cells exist in premalignant tumours but not in malignant ones. Senescence is therefore a defining feature of premalignant tumours that could prove valuable in the diagnosis and prognosis of cancer.
Experiment types
transcription profiling by array, cell type comparison, co-expression, disease state
Contact
Citation
Tumour biology: senescence in premalignant tumours. Manuel Collado, Jesús Gil, Alejo Efeyan, Carmen Guerra, Alberto J Schuhmacher, Marta Barradas, Alberto Benguría, Angel Zaballos, Juana M Flores, Mariano Barbacid, David Beach, Manuel Serrano. Nature 436(7051):642 (2005)
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-2487.idf.txt
Sample and data relationshipE-GEOD-2487.sdrf.txt
Raw data (1)E-GEOD-2487.raw.1.zip
Processed data (1)E-GEOD-2487.processed.1.zip
Array designA-AFFY-33.adf.txt
R ExpressionSetE-GEOD-2487.eSet.r
Links