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E-GEOD-24514 - Expression data from human MSI colorectal cancer and normal colonic mucosa

Status
Released on 1 March 2011, last updated on 2 June 2014
Organism
Homo sapiens
Samples (49)
Array (1)
Protocols (7)
Description
Microsatellite instability (MSI), caused by defective mismatch repair, is observed in a subset of colorectal cancers (CRCs). We evaluated somatic mutations in microsatellite repeats of genes chosen based on reduced expression in MSI CRC and existence of a coding mononucleotide repeat. Expression profiling of 34 MSI colorectal cancers and 15 normal colonic mucosas was performed in 2002. Comparison of malignant and healthy tissue.
Experiment type
transcription profiling by array 
Contacts
Pia Vahteristo <pia.vahteristo@helsinki.fi>, Diego Arango, Lauri A Aaltonen, Pia Alhopuro, Torben F Ørntoft
Citation
Candidate driver genes in microsatellite-unstable colorectal cancer. Alhopuro P, Sammalkorpi H, Niittym�ki I, Bistr�m M, Raitila A, Saharinen J, Nousiainen K, Lehtonen HJ, Heli�vaara E, Puhakka J, Tuupanen S, Sousa S, Seruca R, Ferreira AM, Hofstra RM, Mecklin JP, J�rvinen H, Ristim�ki A, Orntoft TF, Hautaniemi S, Arango D, Karhu A, Aaltonen LA. , PMID:21544814
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-24514.idf.txt
Sample and data relationshipE-GEOD-24514.sdrf.txt
Raw data (2)E-GEOD-24514.raw.1.zip, E-GEOD-24514.raw.2.zip
Processed data (1)E-GEOD-24514.processed.1.zip
Array designA-AFFY-33.adf.txt
Links