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E-GEOD-24051 - Neurological defects in CAIX knockout mice

Status
Released on 31 December 2011, last updated on 11 January 2012
Organism
Mus musculus
Samples (9)
Array (1)
Protocols (6)
Description
To further identify transcriptomic responses to CAIX deficiency in the brain, genome-wide cDNA microarray analyses were performed. Thirty-one and 37 genes were up- and down-regulated in the brain of Car9-/- mice as compared to wild-type mice. Functional annotation revealed that genes with increased expression are mainly involved in alternative splicing, nucleotide binding, RNA binding, and regulation of cellular protein metabolic process; whereas genes with reduced expression are chiefly implicated in cellular cation homeostasis, positive regulation of ion transport, Ubl conjugation, phosphorus metabolic process, and regulation of cell proliferation. Notably, the biological processes behaviour and locomotory behaviour are two prominent over-representation terms among the down-regulated genes, which is consistent with the results obtained from behavioural tests. Brain tissue samples were collected from five wild-type and four CAIX KO mice, respectively, at the age of eight months. Total RNAs were purified and used for cDNA microarray.
Experiment type
transcription profiling by array 
Contacts
Pei-wen Pan <geo@ncbi.nlm.nih.gov>, Anna-Kaisa Parkkila, Jaromir Pastorek, Mika Hilvo, Peiwen Pan, Salla Järventausta, Seppo Parkkila, Silvia Pastorekova
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-24051.idf.txt
Sample and data relationshipE-GEOD-24051.sdrf.txt
Processed data (1)E-GEOD-24051.processed.1.zip
Array designA-GEOD-4055.adf.txt
Links