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E-GEOD-23809 - Molecular studies on sex-different control of the hepatic metabolism in relations to insulin sensitivity (set 2)

Status
Released on 9 August 2011, last updated on 1 May 2014
Organism
Rattus norvegicus
Samples (8)
Array (1)
Protocols (7)
Description
In this study we have analyzed gene expression and metabolite levels in the livers of male and female Zucker diabetic fatty (ZDF) rats. We speculated that the sex different development of diabetes in the ZDF animals presents the opportunity to relate gender to diabetes (since only males become diabetic on normal diet). In this model one can search for parameters that distinguish females fed normal diet compared to high fat diet (i.e. components that vary with the development of diabetes) and evaluate if such changes can be related to components that characterize male diabetic animals.. Biological replicates: 4 male ZDF rat livers from rats on a standard diet (SD) and 4 ZDF female rat livers from rats on a standard diet (SD). One replicate per array. Hepatic gene expression, hepatic metabolites, sex-differences
Experiment type
transcription profiling by array 
Contacts
Carolina Gustavsson <geo@ncbi.nlm.nih.gov>, Carolina E Gustavsson, Gunnar Norstedt, Petra E Tollet-Egnell, Tomoyoshi Soga
Citation
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-23809.idf.txt
Sample and data relationshipE-GEOD-23809.sdrf.txt
Raw data (1)E-GEOD-23809.raw.1.zip
Processed data (1)E-GEOD-23809.processed.1.zip
Array designA-GEOD-6528.adf.txt
R ExpressionSetE-GEOD-23809.eSet.r
Links