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E-GEOD-22991 - Effects of global system for mobile communications 1800 MHz radiofrequency electromagnetic fields on gene expression in MCF-7 cells

Status
Released on 20 July 2010, last updated on 27 March 2012
Organism
Homo sapiens
Samples (8)
Array (1)
Protocols (8)
Description
Despite many studies over a decade, it still remains ambiguous as to the real biological effects induced by radiofrequency electromagnetic fields (RF EMF). Epidemiological studies indicates that long-term exposure to EMF could increase the risk of breast cancer. Some reports have showed that in vitro EMF exposures change cellular gene expression. In this study, we investigated global gene expression responses to RF EMF simulating the Global System for Mobile Communications (GSM) 1800 MHz signal in human breast cancer cell line MCF-7 using transcriptomic approaches. MCF-7 cells were intermittently (5 min fields on/10 min fields off) exposed to RF EMF at an average specific absorption rate (SAR) of 2.0 W/kg (2 W/kg exposure group) or sham-exposed (2 W/kg control group) for 24 h, or exposed to RF EMF at a higher level of 3.5 W/kg (3.5 W/kg exposure group) or sham-exposed (3.5 W/kg control group).
Experiment type
transcription profiling by array 
Contacts
Guangdi Chen, Qunli Zeng, Zhengping Xu
Citation
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-22991.idf.txt
Sample and data relationshipE-GEOD-22991.sdrf.txt
Raw data (1)E-GEOD-22991.raw.1.zip
Processed data (1)E-GEOD-22991.processed.1.zip
Array designA-AFFY-33.adf.txt
Links