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E-GEOD-22597 - Expression data from Fine Needle Aspiration (FNA) biopsies from breast cancer patients

Status
Released on 1 July 2011, last updated on 12 July 2011
Organism
Homo sapiens
Samples (82)
Array (1)
Protocols (8)
Description
This is a stage-matched case control study. Cases with clinical diagnosis of Inflammatory Breast Cancer (IBC) were selected after reviewing all medical records of the 440 FNA samples. IBC was defined as signs of erythema and edema (peau d’orange) involving at least one third of the skin and rapid clinical presentation. Presence of tumor emboli in the dermal lymphatics of the involved skin in the pathology report was not required for inclusion as IBC. Controls were selected to match for T stage, all T4a-c tumors in the data set were included as controls. IBC breast cancer are all T4d breast cancer. We examined if gene expression differences exist between IBC and stage-matched Non-IBC stratified according to hormone receptor and HER2 status. Pre-treatment FNA from primary tumors were obtained and RNA extracted and hybridized to Affymetrix microarrays according to manufacturer protocol.
Experiment type
transcription profiling by array 
Contacts
TAKAYUKI IWAMOTO <tiwamoto@mdanderson.org>, Lajos Pusztai, Massimo Cristofanilli, Naoto T Ueno, Takayuki Iwamoto, Yuan Qi
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-22597.idf.txt
Sample and data relationshipE-GEOD-22597.sdrf.txt
Raw data (2)E-GEOD-22597.raw.1.zip, E-GEOD-22597.raw.2.zip
Processed data (1)E-GEOD-22597.processed.1.zip
Array designA-AFFY-33.adf.txt
R ExpressionSetE-GEOD-22597.eSet.r
Links