Please note that we have stopped the regular imports of Gene Expression Omnibus (GEO) data into ArrayExpress. This may not be the latest version of this experiment.
E-GEOD-22307 - Transcription profiling by array of mouse colon tissues under dextran sodium sulphate induction for 2, 4 and 6 days against uninduced controls at day 0
Released on 13 October 2010, last updated on 30 April 2015
Temporal genome profiling of DSS colitis The DSS induced mouse colitis model is often used to emulate Ulcerative Colitis (UC) in order understand pathophysiological mechanism of inflammatory bowel disease (IBD). Given the progressive nature of IBD, colon tissue gene expression changes during the evolution of disease, and knowing the changes in gene expression profiles could indentify potential diagnostic markers or additional therapeutic targets for colitis. Therefore, we performed temporal genome expression profiling analysis using the Affymetrix genome wide microarray system to identify broad scale changes in gene expression associated with the development of colitis. Keywords: Expression time course of mouse colon tissue induced by 3% DSS. C57BL/6J mice were given 3% DSS in the drinking water and tissues from individual cohorts were collected at days 0, 2, 4 and 6. Total RNA were extracted from the colon tissue and detected by Affymerix GeneChip Mouse Genome 430 2.0 Array.
transcription profiling by array
Kevil G Christopher <firstname.lastname@example.org>, Christopher G Kevil, Kai Fang
Temporal Genome Wide Expression Profiling of DSS Colitis Reveals Novel Inflammatory and Angiogenesis Genes Similar to Ulcerative Colitis. Fang K, Bruce M, Pattillo CB, Zhang S, Stone R 2nd, Clifford J, Kevil CG.