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E-GEOD-22136 - Comparison of splenic and small intestine lamina propria dendritic cells

Status
Submitted on 3 June 2010, released on 16 June 2010, last updated on 10 June 2011
Organism
Mus musculus
Samples (3)
Arrays (2)
Protocols (8)
Description
This SuperSeries is composed of the following subset Series: GSE22127: Expression profiling of small intestine lamina propria dendritic cells GSE22128: Expression profiling of splenic dendritic cells Dendritic cells play a vital role in initiating robust immunity against pathogens as well as maintaining immunological tolerance to self antigens, food antigens and intestinal commensals. However, the intracellular signaling networks that program DCs to become tolerogenic are largely unknown. To address this, we analyzed gene expression profiles using microarray analysis of purified intestinal lamina propria DCs (CD11c+ CD11b+ DCs and CD11c+ CD11b- DCs) and compared it to splenic DCs (CD11c+ DC), from mice. We sought to determine the unique genetic profile of small intestine lamina propria CD11c+ cells compared to splenic CD11c+ cells. We performed a meta-analysis using the expression profiles of Intestinal lamina propria CD11c+ CD11b+ DCs (GSM550122), Intestinal lamina propria CD11c+ CD11b- DCs (GSM550121) and Splenic CD11c+ DCs (GSM550126). This study combined and re-normalized the microarray data from GSE22127 and GSE22128 studies. Refer to individual Series for additional details
Experiment type
transcription profiling by array 
Contact
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-22136.idf.txt
Sample and data relationshipE-GEOD-22136.sdrf.txt
Raw data (1)E-GEOD-22136.raw.1.zip
Processed data (1)E-GEOD-22136.processed.1.zip
Array designsA-AFFY-130.adf.txt, A-AFFY-45.adf.txt
R ExpressionSetE-GEOD-22136.eSet.r
Links