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E-GEOD-21816 - Gene expression profiling of BHDS-associated renal tumors

Status
Released on 21 December 2010, last updated on 2 May 2014
Organism
Homo sapiens
Samples (18)
Array (1)
Protocols (7)
Description
Renal tumors that arise in individuals with BHD Syndrome represent a molecularly distinct form of renal cancer. In addition, BHD syndrome is due to a mutation the folliculin gene (FLCN). While the folliculin gene is an important tumor suppressor gene, the molecular function of this gene is not well defined. By analyzing tumor samples that contain FLCN mutations, we demonstrate that the FLCN gene is an important regulator of mitochondrial function. Gene expression profiling of BHDS tumors and normal kidney tissues
Experiment type
transcription profiling by array 
Contacts
Jeff Klomp
Citation
Birt-Hogg-Dubé renal tumors are genetically distinct from other renal neoplasias and are associated with up-regulation of mitochondrial gene expression. Klomp JA, Petillo D, Niemi NM, Dykema KJ, Chen J, Yang XJ, Sääf A, Zickert P, Aly M, Bergerheim U, Nordenskjöld M, Gad S, Giraud S, Denoux Y, Yonneau L, Méjean A, Vasiliu V, Richard S, Mackeigan JP, Teh BT, Furge KA. , PMID:21162720
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-21816.idf.txt
Sample and data relationshipE-GEOD-21816.sdrf.txt
Processed data (1)E-GEOD-21816.processed.1.zip
Array designA-GEOD-10175.adf.txt
Links