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E-GEOD-21339 - Cytokine interactome alterations promote oropharyngeal Epstien-barr virus (EBV) replication and shedding during HIV infection

Status
Released on 15 April 2010, last updated on 10 June 2011
Organism
Homo sapiens
Samples (3)
Array (1)
Protocols (8)
Description
Proteomic analysis of cytokines in unstimulated oropharyngeal secretions. Epstein-barr virus (EBV) is a type 1 carcinogen which causes many cancers in humans. Here we explored the cytokine involvement of the EBV replication process in the oropharynx. Cytokine interactomic profiles were geneerated to understand the involved signalling pathways in HIV infected group and the healthy group. Proteome profilers were used to understand the major cytokine expression levels that are related to infection and immune regulation. We analyzed unstimulated oropharyngeal samples (UOPS) from 42 healthy subjects and 72 HIV positive subjects using the R & D Proteome Profiler array panels. No techinical replicates were performed. 14 samples in HIV group without therapy (NHAART group); 58 HIV patients with highly active antiretroviral therapy (HAART group); 42 samples in healthy group
Experiment type
proteomic profiling by array 
Contacts
R A P M Perera <h0696905@hkusua.hku.hk>, C S Miller, C S Tsang, K H Chan, L P Samaranayake, M P Lee, P Li, R A Perera
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-21339.idf.txt
Sample and data relationshipE-GEOD-21339.sdrf.txt
Processed data (1)E-GEOD-21339.processed.1.zip
Array designA-GEOD-10327.adf.txt
Links