Please note that we have stopped the regular imports of Gene Expression Omnibus (GEO) data into ArrayExpress. This may not be the latest version of this experiment.
E-GEOD-21305 - Profiling neuroblastoma SH-SY5Y with Paraquat treatment
Released on 22 December 2010, last updated on 27 March 2012
Human SH-SY5Y neuroblastoma cells treated with paraquat, a neurotoxic herbicide which both catalyzes the formation of reactive oxygen species (ROS) and induces mitochondrial damage in animal models was profiled using Affimetrix Exon 1.0 ST GeneChips® Human SH-SY5Y neuroblastoma cells was compared with respect to Human SH-SY5Y neuroblastoma cells treated with Paraquat. Parqaut treatment was done as described by Maracchioni, A., Totaro, A., Angelini, D.F., Di Penta, A., Bernardi, G., Carri, M.T., and Achsel, T. (2007) J Neurochem 100, 142-153
transcription profiling by array
Alessia Maracchioni, Davide Bonanno, Donatella Biancolini, Francesca Zolezzi, Giuseppe Lamorte, MariaTeresa Carrì, Mauro Cozzolino, Raffaele A Calogero, Remo Sanges, Silvia Barabino, Silvia C Lenzken, Tilmann Achsel, Valentina Romeo
Mutant SOD1 and mitochondrial damage alter expression and splicing of genes controlling neuritogenesis in models of neurodegeneration. Lenzken SC, Romeo V, Zolezzi F, Cordero F, Lamorte G, Bonanno D, Biancolini D, Cozzolino M, Pesaresi MG, Maracchioni A, Sanges R, Achsel T, Carrì MT, Calogero RA, Barabino SM. , PMID:21120952