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E-GEOD-20602 - Human nephrosclerosis triggers a hypoxia-related glomerulopathy

Status
Released on 30 March 2010, last updated on 6 November 2020
Organism
Homo sapiens
Samples (18)
Array (1)
Protocols (6)
Description
Expression data from microdissected glomeruli to examine the role of hypoxia in glomerulosclerosis of human Nephrosclerosis (NSC). Human Kidney biopsies of patients with NSC (n=14) and TN (n=4) were selected for RNA extraction and hybridization on Affymetrix microarrays. Gene expression data was then analysed using Genepattern and Genomatix software suites which revealed that CXCR4/CXCL12 plays a role in human NSC and therefore indicate that hypoxia contributes to glomerular damage in NSC.
Experiment type
transcription profiling by array 
Contacts
Preethi Sankaranarayanan <spreeti@umich.edu>, Matthias A Neusser, Matthias Kretzler
Citation
Human nephrosclerosis triggers a hypoxia-related glomerulopathy. Neusser MA, Lindenmeyer MT, Moll AG, Segerer S, Edenhofer I, Sen K, Stiehl DP, Kretzler M, Gröne HJ, Schlöndorff D, Cohen CD. , PMID:20019191
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-20602.idf.txt
Sample and data relationshipE-GEOD-20602.sdrf.txt
Raw data (1)E-GEOD-20602.raw.1.zip
Processed data (1)E-GEOD-20602.processed.1.zip
Array designA-AFFY-33.adf.txt
Links