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E-GEOD-20211 - Transcription profiling by array of human chronic lymphocytic leukemia cells after treatment with LMP-420

Status
Released on 1 February 2011, last updated on 30 April 2015
Organism
Homo sapiens
Samples (26)
Array (1)
Protocols (8)
Description
[original title] LMP-420: a novel purine nucleoside analogue with potent cytotoxic effects for chronic lymphocytic leukemia cells and minimal toxicity for normal hematopoietic cells. LMP-420 induces cytotoxicity and apoptosis to CLL cells in vitro without any negative effects to normal immune cells. This gene expression experiment compares CLL cells treated with LMP-420 versus media alone to investigate the mechanism of action of LMP-420. CLL cells from 13 patients were treated with LMP-420 or media for 24 hours, then RNA was extracted and assayed on U133Plus2 GeneChips.
Experiment types
transcription profiling by array, compound based treatment
Contacts
Daphne R Friedman, George Cianciolo, J B Weinberg, Jon P Gockerman, Joseph O Moore, Karen M Bond, Louis F Diehl, Margaret N Kennedy, Mark C Lanasa, Salvatore V Pizzo, Yvonne M Mowery
Citation
LMP-420: a novel purine nucleoside analog with potent cytotoxic effects for CLL cells and minimal toxicity for normal hematopoietic cells. Mowery YM, Weinberg JB, Kennedy MN, Bond KM, Moore JO, Lanasa MC, Gockerman JP, Diehl LF, Pizzo SV, Cianciolo GJ, Friedman DR.
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-20211.idf.txt
Sample and data relationshipE-GEOD-20211.sdrf.txt
Raw data (1)E-GEOD-20211.raw.1.zip
Processed data (1)E-GEOD-20211.processed.1.zip
Array designA-AFFY-44.adf.txt
Links