E-GEOD-1983 - Transcription profiling of initial stages of metanephric development in mouse and rat
Released on 24 July 2007, last updated on 27 March 2012
Mus musculus, Rattus norvegicus
In this study we identify molecules with highly restricted expression patterns during the initial stages of metanephric development, when the ureteric bud has entered the metanephric mesenchyme and initiated branching morphogenesis. Using the Affymetrix Mouse Genome 430 2.0 Array, we compare gene expression patterns in ureteric bud tips, stalks and metanephric mesenchymes from mouse E12.5 embryos. To identify conserved molecular pathways, we also analyze transcriptional profiles in rat E13.5 ureteric buds and metanephric mesenchymes using the Affymetrix Rat Genome U34 Set. Taken together, these data sets help to identify conserved and highly localized transcripts in the metanephric kidney.
transcription profiling by array, co-expression, organism part comparison, species
Novel regulators of kidney development from the tips of the ureteric bud. Kai M Schmidt-Ott, Jun Yang, Xia Chen, Howard Wang, Neal Paragas, Kiyoshi Mori, Jau-Yi Li, Benson Lu, Frank Costantini, Mario Schiffer, Erwin Bottinger, Jonathan Barasch.