E-GEOD-19314 - Sarcoidosis-specific markers from whole blood gene expression
Released on 10 August 2011, last updated on 18 August 2015
We hypothesized that microarray analyses of whole blood gene expression would identify patterns of gene expression useful in the diagnosis for sacroidosis and identify inflammatory mediators relevant to the underlying pathophysiology. We analyzed whole blood RNA from 37 patients with sarcoidosis, 20 healthy controls and 6 patients with hypersensitivity pneumonitis using genome-wide expression microarrays. We developed a classification algorithm using a derivation and validation subset approach, analyzed the most discriminative gene expression changes, and confirmed selected expression changes using flow-cytometry.
transcription profiling by array
Prescott Gurney Woodruff <email@example.com>, Laura L Koth, Prescott G Woodruff
Sarcoidosis blood transcriptome reflects lung inflammation and overlaps with tuberculosis. Koth LL, Solberg OD, Peng JC, Bhakta NR, Nguyen CP, Woodruff PG.
Longitudinal analysis of sarcoidosis blood transcriptomic signatures and disease outcomes. Su R, Li MM, Bhakta NR, Solberg OD, Darnell EP, Ramstein J, Garudadri S, Ho M, Woodruff PG, Koth LL.