Please note that we have stopped the regular imports of Gene Expression Omnibus (GEO) data into ArrayExpress. This may not be the latest version of this experiment.
E-GEOD-17814 - Role of zyxin in the tension-induced expression change in endothelial cells
Released on 16 August 2010, last updated on 27 March 2012
One of the hallmarks in hypertension is a pressure-induced change in endothelial cell phenotype. A cytoskeletal protein zyxin, which was seen to translocate from focal adhesion contacts to the nucleus in response to the increased wall tensionis, mediates the tension-induced endothelial signaling. Microarrays were used to detail the role of zyxin in the tension-induced expression changes in endothelial cells. Primary endothelial cells (Huvec) from four treatment groups were used for RNA extraction and hybridization on Affymetrix microarrays: wild type under normal condition, wild type under tension, Zyxin-SiRNA-treated under normal condition and Zyxin-SiRNA-treated under tension.
transcription profiling by array
Li Li <firstname.lastname@example.org>, Marco Cattaruzza
Zyxin mediation of stretch-induced gene expression in human endothelial cells. Wójtowicz A, Babu SS, Li L, Gretz N, Hecker M, Cattaruzza M. , PMID:20705921