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E-GEOD-17814 - Role of zyxin in the tension-induced expression change in endothelial cells

Status
Released on 16 August 2010, last updated on 27 March 2012
Organism
Homo sapiens
Samples (12)
Array (1)
Protocols (8)
Description
One of the hallmarks in hypertension is a pressure-induced change in endothelial cell phenotype. A cytoskeletal protein zyxin, which was seen to translocate from focal adhesion contacts to the nucleus in response to the increased wall tensionis, mediates the tension-induced endothelial signaling. Microarrays were used to detail the role of zyxin in the tension-induced expression changes in endothelial cells. Primary endothelial cells (Huvec) from four treatment groups were used for RNA extraction and hybridization on Affymetrix microarrays: wild type under normal condition, wild type under tension, Zyxin-SiRNA-treated under normal condition and Zyxin-SiRNA-treated under tension.
Experiment type
transcription profiling by array 
Contacts
Li Li <li.li@gmx.de>, Marco Cattaruzza
Citation
Zyxin mediation of stretch-induced gene expression in human endothelial cells. Wójtowicz A, Babu SS, Li L, Gretz N, Hecker M, Cattaruzza M. , PMID:20705921
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-17814.idf.txt
Sample and data relationshipE-GEOD-17814.sdrf.txt
Raw data (1)E-GEOD-17814.raw.1.zip
Processed data (1)E-GEOD-17814.processed.1.zip
Array designA-GEOD-9099.adf.txt
R ExpressionSetE-GEOD-17814.eSet.r
Links