E-GEOD-1764 - Transcription profiling of human muscle biopsies from Duchenne muscular dystrophy subjects treated with oxandrolone
Released on 25 August 2007, last updated on 27 March 2012
Three subjects with Duchenne muscular dystrophy (8.3, 10.4, and 16.7 years old) were studied. Baseline studies included stable isotope infusion followed by gastrocnemius muscle biopsy to determine myosin heavy chain synthesis rates. RNA was isolated from the muscle biopsy as well. The subjects were then treated for 3 months with oxandrolone (a synthetic anabolic steroid, 0.1 mg/kg/day) and the studies repeated.
transcription profiling by array, clinical history, co-expression, individual comparison
Oxandrolone enhances skeletal muscle myosin synthesis and alters global gene expression profile in Duchenne muscular dystrophy. Prabhakaran Balagopal, Robert Olney, Dominique Darmaun, Edward Mougey, Maryann Dokler, Gary Sieck, David Hammond.