E-GEOD-16353 - The profile of cellular and KSHV microRNAs in AIDS_KS biopsies (and normal skin control biopsies)
Submitted on 30 May 2009, released on 22 May 2010, last updated on 10 June 2011
Kaposi sarcoma is the most common cancer in AIDS patients and is typified by red skin lesions. The disease is caused by the KSHV virus (HHV8) and is recognisable by its distinctive red skin lesions. The lesions are KSHV-infected spindle cells, most commonly the lymphatic endothelial and blood vessel endothelial cells (LEC and BEC), plus surrounding stroma. Here we study the microRNA profiles of the KS lesion biopsies in AIDS patients (including both the cellular and KSHV microRNA). There are (n=3) normal skin biopsies from healthy patients and (n=5) AIDS-KS biopsies. Three of the AIDS-KS biopsies were technically replicated and 2 were single hybridisations.
transcription profiling by array
Stephen Henderson <firstname.lastname@example.org>, Amy Hansen, Dimitrios Lagos