E-GEOD-16134 - Transcription profiling by array of human gingival tissue with periodontitis
Released on 21 December 2009, last updated on 28 July 2015
We investigated the association between subgingival bacterial profiles and gene expression patterns in gingival tissues of patients with periodontitis. A total of 120 patients undergoing periodontal surgery contributed with a minimum of two interproximal gingival papillae (range 2-4) from a maxillary posterior. Prior to tissue harvesting, subgingival plaque samples were collected from the mesial and distal aspects of each papilla. Gingival tissue RNA was extracted, reverse-transcribed, labeled, and hybridized with whole-genome microarrays (310 in total)
transcription profiling by array
Panos N Papapanou, Paul Pavlidis, Ryan T Demmer
Subgingival bacterial colonization profiles correlate with gingival tissue gene expression. Papapanou PN, Behle JH, Kebschull M, Celenti R, Wolf DL, Handfield M, Pavlidis P, Demmer RT.