Please note that we have stopped the regular imports of Gene Expression Omnibus (GEO) data into ArrayExpress. This may not be the latest version of this experiment.
E-GEOD-1561 - Transcription profiling of human inflammatory breast carcinoma tumors (luminal, basal and apocrine)
Submitted on 14 July 2004, released on 14 August 2007, last updated on 27 March 2012
EORTC 10994 is a phase III clinical trial comparing FEC with ET in patients with large operable, locally advanced or inflammatory breast cancer (www.eortc.be). Frozen biopsies were taken at randomisation. RNA was extracted from 100um thickness of 14G core needle biopsies. Adjacent sections were tested by H&E to confirm >20% tumour cell content. 100 ng total RNA per chip were amplified using the Affymetrix small sample protocol (IVT then Enzo). 49 tumours were tested on Affymetrix U133A chips. The CEL files were quantile normalised together using rma. Clinical response data are not available yet. See doi:10.1038/sj.onc.1208561 Farmer et al "Identification of molecular apocrine breast tumours by microarray analysis
transcription profiling by array, co-expression, disease state
Identification of molecular apocrine breast tumours by microarray analysis. Pierre Farmer, Herve Bonnefoi, Veronique Becette, Michele Tubiana-Hulin, Pierre Fumoleau, Denis Larsimont, Gaetan Macgrogan, Jonas Bergh, David Cameron, Darlene Goldstein, Stephan Duss, Anne-Laure Nicoulaz, Cathrin Brisken, Maryse Fiche, Mauro Delorenzi, Richard Iggo. Oncogene 24(29):4660-71 (2005)