Please note that we have stopped the regular imports of Gene Expression Omnibus (GEO) data into ArrayExpress. This may not be the latest version of this experiment.
E-GEOD-15103 - Transcription profiling of human embryonal rhabdomyosarcoma (EMRS) culture to identify PAX3-FKHR regulated genes differentially expressed between alveolar and embryonal rhabdomyosarcomas
Submitted on 4 March 2009, released on 14 March 2009, last updated on 4 May 2014
The overall goal and objective is to study the degree to which PAX3-FKHR accounts for differences between ARMS and ERMS by expressing a construct (termed P3FK/ER) consisting of PAX3-FKHR joined to the estrogen receptor ligand binding domain in an ERMS cell culture system. Experiment Overall Design: In the study design, three populations of RD ERMS cells expressing P3FK/ER were treated with or without 30 nM 4-hydroxytamoxifen and three control populations transduced with vector only (pK1) were similarly treated.
transcription profiling by array, unknown experiment type
Identification of PAX3-FKHR-regulated genes differentially expressed between alveolar and embryonal rhabdomyosarcoma: focus on MYCN as a biologically relevant target. Gabriela E Mercado, Shujuan J Xia, Chune Zhang, Eun Hyun Ahn, Donna M Gustafson, Marick Laé, Marc Ladanyi, Frederic G Barr.