Please note that we have stopped the regular imports of Gene Expression Omnibus (GEO) data into ArrayExpress. This may not be the latest version of this experiment.
E-GEOD-13645 - Transcriptional profiling of p56lck-deficient regulatory and memory T cells
Submitted on 18 November 2008, released on 22 May 2010, last updated on 1 May 2014
Signaling through the T cell antigen receptor is essential for the formation of regulatory T (Treg) cells in the thymus and for their involvement in antigen-directed suppression of immune responses. Using a conditional null allele of the gene encoding p56Lck we show here that T cell antigen receptor (TCR) signaling is also essential for sustaining the phenotype and homeostasis of Treg cells. Inactivation of p56Lck in Treg cells resulted in large-scale changes in their gene expression profile, blocked their capacity to suppress responses, inhibited their proliferation, and caused them to redistribute in the body. The results make clear multiple aspects of the Treg cell phenotype that are dependent on a sustained capacity to respond through their TCRs. Keywords: Genetic deficiency of p56lck Two-condition experiment: wild-type memory or regulatory T cells versus lck-deficient memory or regulatory T cells.
transcription profiling by array
Mark Klinger <email@example.com>, Nigel Killeen
Impact of the TCR signal on regulatory T cell homeostasis, function, and trafficking. Kim JK, Klinger M, Benjamin J, Xiao Y, Erle DJ, Littman DR, Killeen N.