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E-GEOD-12803 - Gene expression in human myeloid cells

Released on 10 December 2008, last updated on 27 March 2012
Homo sapiens
Samples (20)
Array (1)
Protocols (14)
Human myelopoiesis is an exciting biological model for cellular differentiation since it represents a plastic process where pluripotent stem cells gradually limit their differentiation potential, generating different precursor cells which finally evolve into distinct terminally differentiated cells. This study aimed at investigating the genomic expression during myeloid differentiation through a computational approach that integrates gene expression profiles with functional information and genome organization. The genomic distribution of myelopoiesis genes was investigated integrating transcriptional and functional characteristics of genes. The analysis of genomic expression during human myelopoiesis using an integrative computational approach allowed discovering important relationships between genomic position, biological function and expression patterns and highlighting chromatin domains, including genes with coordinated expression and lineage-specific functions. Keywords: cell differentiation Gene expression data from 20 experiments for 8 different cell types of the human myelopoietic lineage were used to generate an integrated myelopoiesis dataset.
Experiment type
transcription profiling by array 
Motif discovery in promoters of genes co-localized and co-expressed during myeloid cells differentiation. Coppe A, Ferrari F, Bisognin A, Danieli GA, Ferrari S, Bicciato S, Bortoluzzi S. , PMID:19059999
Genomic expression during human myelopoiesis. Ferrari F, Bortoluzzi S, Coppe A, Basso D, Bicciato S, Zini R, Gemelli C, Danieli GA, Ferrari S. , PMID:17683550
Investigation descriptionE-GEOD-12803.idf.txt
Sample and data relationshipE-GEOD-12803.sdrf.txt
Raw data (1)
Processed data (1)
Array designA-AFFY-33.adf.txt
R ExpressionSetE-GEOD-12803.eSet.r