E-GEOD-12310 - Transcription profiling of mouse normal lymphoid progenitors and MLL-AF4 leukemic lymphoblasts

Submitted on 31 July 2008, released on 13 November 2008, last updated on 27 March 2012
Mus musculus
Samples (39)
Array (1)
Protocols (3)
We created a mouse model where conditional expression of physiologic levels of an Mll-AF4 fusion oncogene induces development of acute lymphoblastic (ALL) or acute myeloid leukemias (AML). Immunophenotypic and gene expression analysis of the ALL cells demonstrated bone marrow replacement with B-precursor cells which express a gene expression profile that has significant overlap with profiles in human MLL-rearranged ALL. Experiment Overall Design: Total RNA from normal pro-B, pre-B, immature B and mature B lymphocytes, and from leukemic pre-B cells was isolated and hybridized to Affymetrix expresison microarrays.
Experiment types
transcription profiling by array, unknown experiment type
H3K79 methylation profiles define murine and human MLL-AF4 leukemias. Andrei V Krivtsov, Zhaohui Feng, Madeleine E Lemieux, Joerg Faber, Sridhar Vempati, Amit U Sinha, Xiaobo Xia, Jonathan Jesneck, Adrian P Bracken, Lewis B Silverman, Jeffery L Kutok, Andrew L Kung, Scott A Armstrong.
Investigation descriptionE-GEOD-12310.idf.txt
Sample and data relationshipE-GEOD-12310.sdrf.txt
Raw data (1)E-GEOD-12310.raw.1.zip
Processed data (1)E-GEOD-12310.processed.1.zip
Array designA-AFFY-36.adf.txt
R ExpressionSetE-GEOD-12310.eSet.r