E-GEOD-12310 - Transcription profiling of mouse normal lymphoid progenitors and MLL-AF4 leukemic lymphoblasts
Submitted on 31 July 2008, released on 13 November 2008, last updated on 27 March 2012
We created a mouse model where conditional expression of physiologic levels of an Mll-AF4 fusion oncogene induces development of acute lymphoblastic (ALL) or acute myeloid leukemias (AML). Immunophenotypic and gene expression analysis of the ALL cells demonstrated bone marrow replacement with B-precursor cells which express a gene expression profile that has significant overlap with profiles in human MLL-rearranged ALL. Experiment Overall Design: Total RNA from normal pro-B, pre-B, immature B and mature B lymphocytes, and from leukemic pre-B cells was isolated and hybridized to Affymetrix expresison microarrays.
transcription profiling by array, unknown experiment type
H3K79 methylation profiles define murine and human MLL-AF4 leukemias. Andrei V Krivtsov, Zhaohui Feng, Madeleine E Lemieux, Joerg Faber, Sridhar Vempati, Amit U Sinha, Xiaobo Xia, Jonathan Jesneck, Adrian P Bracken, Lewis B Silverman, Jeffery L Kutok, Andrew L Kung, Scott A Armstrong.