E-GEOD-1139 - Transcription profiling of mouse fast and slow invading C6 glial cells
Submitted on 23 March 2004, released on 27 October 2007, last updated on 10 June 2011
Identification of genes mediating glioma invasion promotes the understanding of glia motility and might result in biologically based therapeutic approaches. To evaluate migration mechanisms operating in vitro versus in vivo, we used C6 rat glioma cells for selecting highly migratory cells in a monolayer migration assay (C6) as well as in brains of nude mice (C6SPGFP), and analyzed in each paradigm the expression profiles of these fast" cells versus those of the original "slow" cells.
transcription profiling by array, cell type comparison, co-expression