Please note that we have stopped the regular imports of Gene Expression Omnibus (GEO) data into ArrayExpress. This may not be the latest version of this experiment.
E-GEOD-11253 - Transcription profiling of mouse Rb, p130 and p107 deficient hematopoietic stem Cells
Released on 11 June 2008, last updated on 10 June 2011
Loss of Rb family in HSCs results in a severe phenotype, such as enhanced proliferation and increase in stem cell number. In addition, HSCs were higly mobilized but failed to transplant. Rb family deficient mice rapidly exhibit a myeloproliferative disease with eosinophilic characteristics. Meanwhile, the lymphoid compartment was severely decreased, due to high apoptotic activity in this lineage. Experiment Overall Design: We used mice that harbor floxed alleles for the Rb family and we induced the recombination by 6 weeks of age. KLS (c-Kit+ Lin - Sca-1+) cells were sorted 2 months after the recombination. Experiment Overall Design: Total of 6 hybridizations done. One Sample was excluded from our analysis based on high background and anomalous control probeset values.
transcription profiling by array, unknown experiment type