E-GEOD-1109 - CEA_SGF:E00002#REtsAF-Bcl2_ZVAD
Submitted on 5 March 2004, released on 1 June 2004, last updated on 27 March 2012
p53 can induce apoptosis through multiple mechanisms including transactivation, transrepression or protein interactions but the determinism of the choice between them is poorly understood. In order to know the role of caspases in this choice, effect of caspase inhibition by ZVAD on p53 target genes transcription is tested by DNA chip analysis.
unknown experiment type
Transcriptional repression by p53 promotes a Bcl-2-insensitive and mitochondria-independent pathway of apoptosis. Godefroy N, Bouleau S, Gruel G, Renaud F, Rincheval V, Mignotte B, Tronik-Le Roux D, Vayssière JL.