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E-GEOD-10957 - Transcription profiling of human A549 lung cancer cells and their isogenic mitochondrial DNA (mtDNA)-depleted rho zero counterparts grown in cell culture and as tumor xenografts in immune-deficient mice

Status
Submitted on 26 March 2008, released on 11 June 2008, last updated on 10 June 2011
Organism
Homo sapiens
Samples (14)
Array (1)
Protocols (11)
Description
Interactions between the gene products encoded by the mitochondrial and nuclear genomes play critical roles in normal eukaryotic cellular function. Here, we characterized the metabolic and transcriptional properties of A549 lung cancer cells and their isogenic mitochondrial DNA (mtDNA)-depleted rho zero counterparts grown in cell culture and as tumor xenografts in immune-deficient mice. A manuscript summarizing our conclusions is under review. Experiment Overall Design: A549 rho zero and their parental A549 cells were grown in culture and as xenografts in nude mice. All experiments conducted in culture were performed in triplicate (6 experiments total) and all experiments conducted in xenografts were performed in quadruplicate (8 experiments total). A manuscript summarizing our experimental design is under review.
Experiment types
transcription profiling by array, unknown experiment type
Contact
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-10957.idf.txt
Sample and data relationshipE-GEOD-10957.sdrf.txt
Raw data (1)E-GEOD-10957.raw.1.zip
Processed data (1)E-GEOD-10957.processed.1.zip
Experiment designE-GEOD-10957.biosamples.png, E-GEOD-10957.biosamples.svg
Array designA-AFFY-33.adf.txt
R ExpressionSetE-GEOD-10957.eSet.r
Links