E-GEOD-10758 - Transcription profiling of human trisomy 21 amniocytes and euploid amniocytes

Status
Submitted on 7 March 2008, released on 3 April 2008, last updated on 1 May 2014
Organism
Homo sapiens
Samples (20)
Array (1)
Protocols (7)
Description
Congenital development disorders with variable severity occur in trisomy 21. However, how these phenotypic abnormalities develop with variations remains elusive. We hypothesize that the difference in euploidy gene expression variation among trisomy 21 tissues are perturbed by the presence of an extra copy of chromosome 21 and this may contribute to the phenotypic variations in Down syndrome. Experiment Overall Design: We used DNA microarray to measure the differences in gene expression variance (representing variation) between four human trisomy 21 amniocytes and six human euploid amniocytes.
Experiment types
transcription profiling by array, unknown experiment type
Contact
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-10758.idf.txt
Sample and data relationshipE-GEOD-10758.sdrf.txt
Processed data (1)E-GEOD-10758.processed.1.zip
Additional data (1)E-GEOD-10758.additional.1.zip
Experiment designE-GEOD-10758.biosamples.png, E-GEOD-10758.biosamples.svg
Array designA-AGIL-9.adf.txt
Links