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E-GEOD-10526 - Transcription profiling of human oral keratinocytes was utilized to define the biological role of P. gingivalis in gingival epithelial cell cytoskeletal remodeling and cytokine production

Status
Submitted on 14 February 2008, released on 18 June 2008, last updated on 10 June 2011
Organism
Homo sapiens
Samples (8)
Array (1)
Protocols (6)
Description
Transcriptional profiling of oral keratinocytes was utilized to define the biological role of P. gingivalis SerB. We used microarrays to detail the global programme of gene expression underlying infection with an isogenic mutant in SerB, and identified distinct classes of up- and down-regulated genes during this process. Experiment Overall Design: Gingival epithelial HIGK cells were infected with either the oral pathogen P. gingivalis (Pg) or an isogenic mutant for SerB in the same parental strain in order to gain a better understanding on the role of SerB. These samples were hybridized to Affymetrix microarrays. SerB was found to be a multifunctional invasin and modulin of P. gingivalis and associated with broadly based regulation of the epithelial cell transcriptome.
Experiment types
transcription profiling by array, unknown experiment type
Contact
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-10526.idf.txt
Sample and data relationshipE-GEOD-10526.sdrf.txt
Raw data (1)E-GEOD-10526.raw.1.zip
Processed data (1)E-GEOD-10526.processed.1.zip
Array designA-AFFY-33.adf.txt
Links