E-CBIL-8 - Transcription profiling of rat pancreatic beta-cells in response to INF gamma and/or IL-1 beta treatment for 6 or 24 hours

Released on 27 May 2006, last updated on 12 October 2011
Rattus norvegicus
Samples (30)
Array (1)
Protocols (9)
Type 1 diabetes is an autoimmune disease resulting from the selective destruction of insulin-producing beta-cells. Beta cell culture for 6-9 days in the presence of IL-1 beta and interferon (INF) gamma leads to apoptosis. Primary rat beta-cells were FACS purified and exposed for 6 or 24 h to control condition, IL-1 beta + INF gamma, or IL-1 beta alone (24 h only). The gene expression profile was analyzed by hybridization in duplicate to the Affymetrix RG U34A microarray.
Experiment types
transcription profiling by array, compound treatment, time series
Identification of novel cytokine-induced genes in pancreatic beta-cells by high-density oligonucleotide arrays. Alessandra K. Cardozo, Mogens Kruhøffer, Ruth Leeman, Torben Ørntoft, and Décio L. Eizirik.
Investigation descriptionE-CBIL-8.idf.txt
Sample and data relationshipE-CBIL-8.sdrf.txt
Processed data (1)E-CBIL-8.processed.1.zip
Experiment designE-CBIL-8.biosamples.png, E-CBIL-8.biosamples.svg
Array designA-AFFY-18.adf.txt