E-CBIL-7 - Transcription profiling of mouse islets treated with PANcreatic DERived factor for 48 or 72 h to elucidate the genetic mechanisms of PANDER-induced cell death
Released on 24 May 2006, last updated on 2 June 2014
Expression profiling using the UPenn Mouse PancChip 5.0 was used to elucidate the genetic mechanisms of PANDER-induced cell death in pancreatic islets. Murine islets were treated with PANDER (PANcreatic DERived factor) for 48 or 72 h (n=4 and n=3 respectively). Following linear amplification, the RNA was matched for purity using Quantitative PCR.
transcription profiling by array, compound treatment, time series
PANDER-induced cell-death genetic networks in islets reveal central role for caspase-3 and cyclin-dependent kinase inhibitor 1A (p21). Brant R. Burkhardt, Scott R. Greene, Peter White, Ryan K. Wong, John E. Brestelli, Jichun Yang, Claudia E. Robert, Todd M. Brusko, Clive H. Wasserfall, Jianmei Wu, Mark A. Atkinson, Zhiyong Gao, Klaus H. Kaestner and Bryan A. Wolf.