E-CBIL-41 - Transcription profiling of pig aortic endothelial cells to investigate the impact of gender, high fat/high cholesterol diet and regional hemodynamics on gene expression
Released on 15 December 2007, last updated on 14 April 2015
Atherosclerosis preferentially develops in susceptible regions of the arterial system that are defined by the regional vascular hemodynamics. Previous work in adult castrate male pigs revealed the coexistence of pro- and anti-atherosclerotic profiles in endothelial cell gene expression in disturbed flow regions of arteries in the absence of risk factors for atherogenesis. This study investigates the impact of gender, high fat/high cholesterol diet and regional hemodynamics on arterial endothelial cell gene expression profiles in sexually mature intact pigs.
transcription profiling by array, growth condition, organism part comparison, reference, sex
Peter Davies <email@example.com>, Congzhu Shi, Peiying Chuan
Regional determinants of arterial endothelial phenotype dominate the impact of gender or short-term exposure to a high-fat diet. Passerini AG, Shi C, Francesco NM, Chuan P, Manduchi E, Grant GR, Stoeckert CJ Jr, Karanian JW, Wray-Cahen D, Pritchard WF, Davies PF. BBRC 332:142-148 (2005)