E-CBIL-38 - Chromatin immunoprecipitation and transcription of mouse liver in the presence or absence of exogenous glucocorticoid to identify direct targets of the glucocorticoid receptor
Submitted on 27 August 2007, released on 14 September 2007, last updated on 2 June 2014
The purpose of this study was to identify direct targets of the glucocorticoid receptor (GR) using an orthogonal analysis. An expression study of mouse livers in the presence or absence of exogenous glucocorticoid complemented a genome-wide location analysis on chromatin from the same livers. These were hybridized to the BCBC Mouse PancChip 5.0 and the Mouse PromoterChip BCBC-3.0 respectively.
ChIP-chip by array, binding site identification, compound treatment, reference
Glucocorticoid receptor-dependent gene regulatory networks. Phuc Le Phillip, Friedman Joshua R, Schug Jonathan, Brestelli John E, Parker J Brandon, Bochkis Irina M, Kaestner Klaus H. PLoS Genet 1(2):e16 (2005)