E-CBIL-25 - Transcription profiling of mouse skeletal muscle in streptozotocin diabetes with or without insulin treatment
Released on 5 April 2007, last updated on 21 February 2012
Metabolic abnormalities underlying diabetes are primarily the result of the lack of adequate insulin action and the associated changes in protein phosphorylation and gene expression. Affymetrix oligonucleotide microarrays were used to study the changes in the transcriptional program of mouse skeletal muscle in insulin-deficient diabetes. Mice which were made diabetic by streptozotocin treatment were compared to controls. Also, the reversibility of these changes was ascertained by treating a subset of the diabetic mice with insulin.
compound treatment, transcription profiling by array
Coordinated patterns of gene expression for substrate and energy metabolism in skeletal muscle of diabetic mice. Yechoor Vijay K, Patti Mary-Elizabeth, Saccone Robert, Kahn C Ronald.